The drug denosumab has two brand names with two different indications. The brand names and their indications are:
* Prolia® – indicated to treat osteoporosis in women after menopause.
* Xgeva® – indicated for the prevention of Skeletal-Related Events (SREs) in patients with bone metastases from solid tumors.
Indications:
Indications for denosumab (PROLIA™):
• For the treatment of postmenopausal women with osteoporosis at high risk for fracture defined as a history of osteoporotic fracture, or multiple risk factors for fracture;
• For the treatment of postmenopausal women with osteoporosis who have failed or are intolerant to other available osteoporosis therapy.
• Indicated as a treatment to increase bone mass in women at high risk for fracture receiving adjuvant aromatase inhibitor therapy for breast cancer.
• Indicated as a treatment to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for non-metastatic prostate cancer.
• For treatment in men to increase bone mass with osteoporosis at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have failed or are intolerant to other available osteoporosis therapy.
Indications for denosumab (Xgeva™):
• Xgeva™ is approved for the treatment of patients with bone metastases from solid tumors for the prevention of skeletal-related events.
• Xgeva™ is approved for the treatment of adult and skeletally mature adolescent patients with giant cell tumor of bone that is unresectable or where surgical resection is likely to result in severe morbidity.
• Xgeva™ is approved for the treatment of hypercalcemia of malignancy (HCM) refractory to bisphosphonate therapy.
Limitations:
• Denosumab (PROLIA™) is contraindicated in patients with hypocalcemia.
• Denosumab (PROLIA™) is contraindicated in patients with pregnancy.
• Denosumab (Xgeva™) is not approved for patients with multiple myeloma or other cancers of the blood.
How does Prolia work?
Prolia was developed as a result of a scientific understanding of how bones stay strong.
It helps stop the development of bone-removing cells before they can reach and damage the bone.
Prolia works by targeting a molecule that the bone-removing cells need in order to work.
Important Safety Information
Prolia can cause serious side effects. Possible serious side effects include serious allergic reactions, low blood calcium, severe jaw bone problems, unusual thigh bone fractures, serious infections, skin problems, and severe bone, joint, or muscle pain
Without Prolia
When you have postmenopausal osteoporosis, there is an excess of bone-removing cells.
Prolia® targets a molecule that the bone-removing cells need to work.
With Prolia
Prolia has helped stop most of the bone-removing cells from getting to the bone and causing bone loss.
Why Prolia is different.
• Prolia is the first and only prescription medicine for postmenopausal osteoporosis that is a shot given 2 times a year in your doctor’s office
• It’s not a pill, so it doesn’t go down your esophagus or through your stomach
Important Safety Information
You should take calcium and vitamin D as your doctor tells you to while you receive Prolia
Administration:
The recommended dose of Denosumab (Prolia™) for the treatment of osteoporosis in postmenopausal women is 60 milligrams (mg) subcutaneously once every 6 months, plus calcium 1000 mg orally once daily and at least vitamin D 400 international units orally once daily. Administer Denosumab (Prolia™) via subcutaneous injection in the upper arm, the upper thigh, or the abdomen. Denosumab (Prolia™) is supplied in a single-use prefilled syringe with a safety guard or in a single-use vial.
Denosumab (Xgeva™) is administered at a dose of 120mg every four weeks as a subcutaneous injection in the upper arm, upper thigh, or abdomen for bone metastasis from solid tumors.
Denosumab (Xgeva™) is administered at a dose of 120mg every four weeks with an additional 120mg dose on day 8 and 15 of the first month of therapy as a subcutaneous injection in the upper arm, upper thigh, or abdomen for Giant Cell Tumor of the bone. Administer calcium and vitamin D as necessary to treat or prevent hypocalcemia. Denosumab (Xgeva™) is administered at a dose of 120 mg every 4 weeks with additional 120 mg doses on Days 8 and 15 of the first month of therapy for hypercalcemia of malignancy. Administer subcutaneously in the upper arm, upper thigh, or abdome
The Downside Risk of Prolia Injection That No One Is Talking About
Do not utilize Prolia if you're pregnant or attempting to find pregnant. Prolia is not wise for children. Prolia is not suggested for everyone under 18 years old. Prolia is not suggested for breastfeeding mothers because it might not be safe for your infant. Prolia may raise your risk of creating infections. Prolia for osteoporosis is a somewhat recent development which enables users to get benefits by taking injections twice annually.
Do now not utilize Prolia if you're pregnant. Prolia ought to be administered by means of a healthcare professional. Prolia is also utilised to boost bone mass in women and men with a tall risk of bone fracture due to receiving treatments for specific sorts of cancer. In the event that you were taking Prolia, there's a very good chance you weren't warned about the capacity for femur fractures.
Prolia is not advised for use if you're pregnant. In general, Prolia is costlier than oral or intravenous bisphosphonates. Prolia hasn't been tested in pregnant ladies. Prolia isn't recommended in pediatric patients. Prolia is know to result in birth defects and may harm an unborn baby. Not advisable for use Prolia, if you're pregnant.
Whispered Prolia Injection Secrets
In the event the injections do not supply any benefit or fail to supply benefit after a succession of injections as time passes, the demand for surgery is considered. Another kind of injection is called the rooster comb injection. The injections are naturally useful for our entire body and they're non-toxic. So as to boost its absorption, individuals are recommended with vitamin B12 injections.
Please speak to your physician before you consider stopping treatment. Please speak to your physician before you consider stopping the therapy. You might need medical treatment if you receive a number of the side results.
Even patients who don't have any immune system problems could be at higher chance of particular infections such as the ones of the epidermis. Other patients will need to carry on taking this sort of drug on a continuous basis. Most patients with low calcium levels, but do not demonstrate these signs. Once a diagnosis was made, therapy begins. It is necessary to recognize patients at risk for hypocalcaemia. Some, but not all, patients that are at low danger of fracture might be able to quit using the drug after 5 decades. It is most commonly utilized in patients who are not able to bring an oral bisphosphonate as a result of side effects, malabsorption, or inadequate response to therapy.
* Prolia® – indicated to treat osteoporosis in women after menopause.
* Xgeva® – indicated for the prevention of Skeletal-Related Events (SREs) in patients with bone metastases from solid tumors.
Indications:
Indications for denosumab (PROLIA™):
• For the treatment of postmenopausal women with osteoporosis at high risk for fracture defined as a history of osteoporotic fracture, or multiple risk factors for fracture;
• For the treatment of postmenopausal women with osteoporosis who have failed or are intolerant to other available osteoporosis therapy.
• Indicated as a treatment to increase bone mass in women at high risk for fracture receiving adjuvant aromatase inhibitor therapy for breast cancer.
• Indicated as a treatment to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for non-metastatic prostate cancer.
• For treatment in men to increase bone mass with osteoporosis at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have failed or are intolerant to other available osteoporosis therapy.
Indications for denosumab (Xgeva™):
• Xgeva™ is approved for the treatment of patients with bone metastases from solid tumors for the prevention of skeletal-related events.
• Xgeva™ is approved for the treatment of adult and skeletally mature adolescent patients with giant cell tumor of bone that is unresectable or where surgical resection is likely to result in severe morbidity.
• Xgeva™ is approved for the treatment of hypercalcemia of malignancy (HCM) refractory to bisphosphonate therapy.
Limitations:
• Denosumab (PROLIA™) is contraindicated in patients with hypocalcemia.
• Denosumab (PROLIA™) is contraindicated in patients with pregnancy.
• Denosumab (Xgeva™) is not approved for patients with multiple myeloma or other cancers of the blood.
How does Prolia work?
Prolia was developed as a result of a scientific understanding of how bones stay strong.
It helps stop the development of bone-removing cells before they can reach and damage the bone.
Prolia works by targeting a molecule that the bone-removing cells need in order to work.
Important Safety Information
Prolia can cause serious side effects. Possible serious side effects include serious allergic reactions, low blood calcium, severe jaw bone problems, unusual thigh bone fractures, serious infections, skin problems, and severe bone, joint, or muscle pain
Without Prolia
When you have postmenopausal osteoporosis, there is an excess of bone-removing cells.
Prolia® targets a molecule that the bone-removing cells need to work.
With Prolia
Prolia has helped stop most of the bone-removing cells from getting to the bone and causing bone loss.
Why Prolia is different.
• Prolia is the first and only prescription medicine for postmenopausal osteoporosis that is a shot given 2 times a year in your doctor’s office
• It’s not a pill, so it doesn’t go down your esophagus or through your stomach
Important Safety Information
You should take calcium and vitamin D as your doctor tells you to while you receive Prolia
Administration:
The recommended dose of Denosumab (Prolia™) for the treatment of osteoporosis in postmenopausal women is 60 milligrams (mg) subcutaneously once every 6 months, plus calcium 1000 mg orally once daily and at least vitamin D 400 international units orally once daily. Administer Denosumab (Prolia™) via subcutaneous injection in the upper arm, the upper thigh, or the abdomen. Denosumab (Prolia™) is supplied in a single-use prefilled syringe with a safety guard or in a single-use vial.
Denosumab (Xgeva™) is administered at a dose of 120mg every four weeks as a subcutaneous injection in the upper arm, upper thigh, or abdomen for bone metastasis from solid tumors.
Denosumab (Xgeva™) is administered at a dose of 120mg every four weeks with an additional 120mg dose on day 8 and 15 of the first month of therapy as a subcutaneous injection in the upper arm, upper thigh, or abdomen for Giant Cell Tumor of the bone. Administer calcium and vitamin D as necessary to treat or prevent hypocalcemia. Denosumab (Xgeva™) is administered at a dose of 120 mg every 4 weeks with additional 120 mg doses on Days 8 and 15 of the first month of therapy for hypercalcemia of malignancy. Administer subcutaneously in the upper arm, upper thigh, or abdome
The Downside Risk of Prolia Injection That No One Is Talking About
Do not utilize Prolia if you're pregnant or attempting to find pregnant. Prolia is not wise for children. Prolia is not suggested for everyone under 18 years old. Prolia is not suggested for breastfeeding mothers because it might not be safe for your infant. Prolia may raise your risk of creating infections. Prolia for osteoporosis is a somewhat recent development which enables users to get benefits by taking injections twice annually.
Do now not utilize Prolia if you're pregnant. Prolia ought to be administered by means of a healthcare professional. Prolia is also utilised to boost bone mass in women and men with a tall risk of bone fracture due to receiving treatments for specific sorts of cancer. In the event that you were taking Prolia, there's a very good chance you weren't warned about the capacity for femur fractures.
Prolia is not advised for use if you're pregnant. In general, Prolia is costlier than oral or intravenous bisphosphonates. Prolia hasn't been tested in pregnant ladies. Prolia isn't recommended in pediatric patients. Prolia is know to result in birth defects and may harm an unborn baby. Not advisable for use Prolia, if you're pregnant.
Whispered Prolia Injection Secrets
In the event the injections do not supply any benefit or fail to supply benefit after a succession of injections as time passes, the demand for surgery is considered. Another kind of injection is called the rooster comb injection. The injections are naturally useful for our entire body and they're non-toxic. So as to boost its absorption, individuals are recommended with vitamin B12 injections.
Please speak to your physician before you consider stopping treatment. Please speak to your physician before you consider stopping the therapy. You might need medical treatment if you receive a number of the side results.
Even patients who don't have any immune system problems could be at higher chance of particular infections such as the ones of the epidermis. Other patients will need to carry on taking this sort of drug on a continuous basis. Most patients with low calcium levels, but do not demonstrate these signs. Once a diagnosis was made, therapy begins. It is necessary to recognize patients at risk for hypocalcaemia. Some, but not all, patients that are at low danger of fracture might be able to quit using the drug after 5 decades. It is most commonly utilized in patients who are not able to bring an oral bisphosphonate as a result of side effects, malabsorption, or inadequate response to therapy.
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